Ninjurin2 overexpression promotes glioma cell growth.
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ABSTRACT:
SUBMITTER: Zhou LN
PROVIDER: S-EPMC6932907 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Ninjurin2 overexpression promotes glioma cell growth.
Zhou Li-Na LN Li Ping P Cai Shang S Li Gang G Liu Fang F
Aging 20191202 23
Ninjurin2 (Ninj2) is an adhesion protein expressed in neurons and glial cells. The current study tested its expression and potential functions in human glioma. We show that <i>Ninj2 mRNA</i> and protein levels are significantly upregulated in human glioma cells and tissues. In established and primary human glioma cells, Ninj2 shRNA or knockout (by CRISPR/Cas9 gene editing) potently inhibited cell survival, growth, proliferation, cell migration and invasion, while inducing apoptosis activation. C ...[more]
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