Ontology highlight
ABSTRACT:
SUBMITTER: Hoffmann JM
PROVIDER: S-EPMC6933264 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hoffmann Jenny M JM Grünberg John R JR Hammarstedt Ann A Kroon Tobias T Greiner Thomas U TU Maurer Stefanie S Elias Ivet I Palsdottir Vilborg V Bosch Fatima F Boucher Jeremie J Hedjazifar Shahram S Smith Ulf U
Molecular metabolism 20191217
<h4>Objective</h4>Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we examine whether this approach could also reduce established obesity.<h4>Methods</h4>Dietary-induced obese C57BL6/N mice received AAV8 BMP4 gene therapy at 17-18 weeks of age. They were kept on a hi ...[more]