Ontology highlight
ABSTRACT:
SUBMITTER: Michels M
PROVIDER: S-EPMC6933367 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Michels Monique M Abatti Mariane Rocha MR Ávila Pricila P Vieira Andriele A Borges Heloisa H Carvalho Junior Celso C Wendhausen Diogo D Gasparotto Juciano J Tiefensee Ribeiro Camila C Moreira José Claudio Fonseca JCF Gelain Daniel Pens DP Dal-Pizzol Felipe F
Journal of cellular and molecular medicine 20191026 1
We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of minocycline on these phenotypes. Rats were subjected to CLP, and some animals were treated with minocycline (10 ug/kg) by i.c.v. administration. Animals were killed 24 hours, 5, 10 and 30 days after sepsis induction, and serum and hippocampus were collected for subsequent analyses. Real-time PCR was performed for M1 and M2 markers. TNF-α, ...[more]