Ontology highlight
ABSTRACT:
SUBMITTER: Miao J
PROVIDER: S-EPMC6933402 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Miao Jinbai J Kyoyama Hiroyuki H Liu Luwei L Chan Geraldine G Wang Yucheng Y Urisman Anatoly A Yang Yi-Lin YL Liu Shu S Xu Zhidong Z Bin Hu H Li Hui H Jablons David M DM You Liang L
Journal of cellular and molecular medicine 20191121 1
Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway. Here, we investigated the role of CDK7 on YAP regulation in human malignant pleural mesothelioma (MPM). We found that in microarray samples of human MPM tissue, immunohistochemistry staining showed correlation between the expression level of CDK7 and YAP (n = 70, r = .513). In MPM cells, CDK7 expression leve ...[more]