Crosstalk between cancer-associated fibroblasts and immune cells in cancer.

ABSTRACT: Multiple studies have shown that cancer-associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.

SUBMITTER: An Y 

PROVIDER: S-EPMC6933413 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature