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Flexible docking of peptides to proteins using CABS-dock.

ABSTRACT: Molecular docking of peptides to proteins can be a useful tool in the exploration of the possible peptide binding sites and poses. CABS-dock is a method for protein-peptide docking that features significant conformational flexibility of both the peptide and the protein molecules during the peptide search for a binding site. The CABS-dock has been made available as a web server and a standalone package. The web server is an easy to use tool with a simple web interface. The standalone package is a command-line program dedicated to professional users. It offers a number of advanced features, analysis tools and support for large-sized systems. In this article, we outline the current status of the CABS-dock method, its recent developments, applications, and challenges ahead.

SUBMITTER: Kurcinski M

PROVIDER: S-EPMC6933849 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Flexible docking of peptides to proteins using CABS-dock.

Kurcinski Mateusz M Badaczewska-Dawid Aleksandra A Kolinski Michal M Kolinski Andrzej A Kmiecik Sebastian S

Protein science : a publication of the Protein Society 20191111 1

Molecular docking of peptides to proteins can be a useful tool in the exploration of the possible peptide binding sites and poses. CABS-dock is a method for protein-peptide docking that features significant conformational flexibility of both the peptide and the protein molecules during the peptide search for a binding site. The CABS-dock has been made available as a web server and a standalone package. The web server is an easy to use tool with a simple web interface. The standalone package is a ...[more]

PMID: 31682301

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