Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study.

ABSTRACT: OBJECTIVE:Gestational perfluoroalkyl substances exposure has been associated with decreased birthweight. We determined if gestational perfluoroalkyl substances exposure was associated with fetal metabolic markers using data from the HOME Study, a prospective birth cohort of pregnant women and their children in Cincinnati, Ohio. METHODS:Maternal serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid, and perfluorohexane sulfonic acid were quantified. We measured neonatal adipocytokine (leptin and adiponectin) concentrations in umbilical cord serum, and estimated percent differences with a 2-fold increase in maternal perfluoroalkyl substances concentrations among 230 mother-infant pairs. RESULTS:Median maternal serum PFOA and PFOS concentrations were 5.6?ng/mL and 14?ng/mL, respectively. Leptin was positively correlated with infant birthweight (p?

SUBMITTER: Buck CO 

PROVIDER: S-EPMC6933943 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature