Ontology highlight
ABSTRACT:
SUBMITTER: Sinner EK
PROVIDER: S-EPMC6934041 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sinner Erica K EK Lichstrahl Michael S MS Li Rongfeng R Marous Daniel R DR Townsend Craig A CA
Chemical communications (Cambridge, England) 20191201 99
Complex carbapenem β-lactam antibiotics contain diverse C6 alkyl substituents constructed by cobalamin-dependent radical SAM enzymes. TokK installs the C6 isopropyl chain found in asparenomycin. Time-course analyses of TokK and its ortholog ThnK, which forms the C6 ethyl chain of thienamycin, indicate that catalysis occurs through a sequence of discrete, non-processive methyl transfers. ...[more]