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The HEART Pathway Randomized Controlled Trial One-year Outcomes.


ABSTRACT: OBJECTIVE:The objective was to determine the impact of the HEART Pathway on health care utilization and safety outcomes at 1 year in patients with acute chest pain. METHODS:Adult emergency department (ED) patients with chest pain (N = 282) were randomized to the HEART Pathway or usual care. In the HEART Pathway arm, ED providers used the HEART score and troponin measures (0 and 3 hours) to risk stratify patients. Usual care was based on American College of Cardiology/American Heart Association guidelines. Major adverse cardiac events (MACE-cardiac death, myocardial infarction [MI], or coronary revascularization), objective testing (stress testing or coronary angiography), and cardiac hospitalizations and ED visits were assessed at 1 year. Randomization arm outcomes were compared using Fisher's exact tests. RESULTS:A total of 282 patients were enrolled, with 141 randomized to each arm. MACE at 1 year occurred in 10.6% (30/282): 9.9% in the HEART Pathway arm (14/141; 10 MIs, four revascularizations without MI) versus 11.3% in usual care (16/141; one cardiac death, 13 MIs, two revascularizations without MI; p = 0.85). Among low-risk HEART Pathway patients, 0% (0/66) had MACE, with a negative predictive value (NPV) of 100% (95% confidence interval = 93%-100%). Objective testing through 1 year occurred in 63.1% (89/141) of HEART Pathway patients compared to 71.6% (101/141) in usual care (p = 0.16). Nonindex cardiac-related hospitalizations and ED visits occurred in 14.9% (21/141) and 21.3% (30/141) of patients in the HEART Pathway versus 10.6% (15/141) and 16.3% (23/141) in usual care (p = 0.37, p = 0.36). CONCLUSIONS:The HEART Pathway had a 100% NPV for 1-year safety outcomes (MACE) without increasing downstream hospitalizations or ED visits. Reduction in 1-year objective testing was not significant.

SUBMITTER: Stopyra JP 

PROVIDER: S-EPMC6934171 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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The HEART Pathway Randomized Controlled Trial One-year Outcomes.

Stopyra Jason P JP   Riley Robert F RF   Hiestand Brian C BC   Russell Gregory B GB   Hoekstra James W JW   Lefebvre Cedric W CW   Nicks Bret A BA   Cline David M DM   Askew Kim L KL   Elliott Stephanie B SB   Herrington David M DM   Burke Gregory L GL   Miller Chadwick D CD   Mahler Simon A SA  

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20180719 1


<h4>Objective</h4>The objective was to determine the impact of the HEART Pathway on health care utilization and safety outcomes at 1 year in patients with acute chest pain.<h4>Methods</h4>Adult emergency department (ED) patients with chest pain (N = 282) were randomized to the HEART Pathway or usual care. In the HEART Pathway arm, ED providers used the HEART score and troponin measures (0 and 3 hours) to risk stratify patients. Usual care was based on American College of Cardiology/American Hear  ...[more]

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