Ontology highlight
ABSTRACT:
SUBMITTER: Uemura N
PROVIDER: S-EPMC6934438 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Uemura Norihito N Uemura Maiko T MT Lo Angela A Bassil Fares F Zhang Bin B Luk Kelvin C KC Lee Virginia M-Y VM Takahashi Ryosuke R Trojanowski John Q JQ
Journal of neuropathology and experimental neurology 20191001 10
Synucleinopathies are composed of Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Alpha-synuclein (α-Syn) forms aggregates mainly in neurons in PD and DLB, while oligodendroglial α-Syn aggregates are characteristic of MSA. Recent studies have demonstrated that injections of synthetic α-Syn preformed fibrils (PFFs) into the brains of wild-type (WT) animals induce intraneuronal α-Syn aggregates and the subsequent interneuronal transmission of α-Syn aggre ...[more]