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Transcriptome-wide analysis of the SCNT bovine abnormal placenta during mid- to late gestation.


ABSTRACT: The dysfunction of placenta is common in somatic cell nuclear transfer (SCNT) cloned cattle and would cause aberrant fetal development and even abortion, which occurred with highest rate at the mid- to late gestation. However, the mechanism of abnormal placentas was unclear. To analyze the transcriptome-wide characteristics of abnormal placentas in SCNT cloned cattle, the mRNA, lncRNA and miRNA of placental cotyledon tissue at day 180 after gestation were sequenced. A total of 19,055 mRNAs, 30,141 lncRNAs and 684 miRNAs were identified. Compared with control group, 362 mRNAs, 1,272 lncRNAs and nine miRNAs (six known and three novel miRNAs) were differentially expressed (fold change???2 and P-value?

SUBMITTER: Gao G 

PROVIDER: S-EPMC6934727 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Transcriptome-wide analysis of the SCNT bovine abnormal placenta during mid- to late gestation.

Gao Guangqi G   Wang Shenyuan S   Zhang Jiaqi J   Su Guanghua G   Zheng Zhong Z   Bai Chunling C   Yang Lei L   Wei Zhuying Z   Wang Xiuying X   Liu Xiao X   Guo Ziru Z   Li Guangpeng G   Su Xiaohu X   Zhang Li L  

Scientific reports 20191227 1


The dysfunction of placenta is common in somatic cell nuclear transfer (SCNT) cloned cattle and would cause aberrant fetal development and even abortion, which occurred with highest rate at the mid- to late gestation. However, the mechanism of abnormal placentas was unclear. To analyze the transcriptome-wide characteristics of abnormal placentas in SCNT cloned cattle, the mRNA, lncRNA and miRNA of placental cotyledon tissue at day 180 after gestation were sequenced. A total of 19,055 mRNAs, 30,1  ...[more]

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