Ontology highlight
ABSTRACT:
SUBMITTER: Lukowicz C
PROVIDER: S-EPMC6934754 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lukowicz Céline C Ellero-Simatos Sandrine S Régnier Marion M Oliviero Fabiana F Lasserre Frédéric F Polizzi Arnaud A Montagner Alexandra A Smati Sarra S Boudou Frédéric F Lenfant Françoise F Guzylack-Pirou Laurence L Menard Sandrine S Barretto Sharon S Fougerat Anne A Lippi Yannick Y Naylies Claire C Bertrand-Michel Justine J Belgnaoui Afifa Ait AA Theodorou Vassilia V Marchi Nicola N Gourdy Pierre P Gamet-Payrastre Laurence L Loiseau Nicolas N Guillou Hervé H Mselli-Lakhal Laïla L
Scientific reports 20191227 1
Metabolic diseases such as obesity, type II diabetes and hepatic steatosis are a public health concern in developed countries. The metabolic risk is gender-dependent. The constitutive androstane receptor (CAR), which is at the crossroads between energy metabolism and endocrinology, has recently emerged as a promising therapeutic agent for the treatment of obesity and type 2 diabetes. In this study we sought to determine its role in the dimorphic regulation of energy homeostasis. We tracked male ...[more]