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Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL.


ABSTRACT: The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood-brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.

SUBMITTER: Farhadian SF 

PROVIDER: S-EPMC6934883 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL.

Farhadian Shelli F SF   Mistry Hetal H   Kirchwey Tobias T   Chiarella Jennifer J   Calvi Rachela R   Chintanaphol Michelle M   Patel Payal P   Landry Marie L ML   Robertson Kevin K   Spudich Serena S SS  

Open forum infectious diseases 20191214 12


The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood-brain barrier integri  ...[more]

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