Ontology highlight
ABSTRACT:
SUBMITTER: Valipour M
PROVIDER: S-EPMC6934981 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Iranian journal of pharmaceutical research : IJPR 20190101 3
Alzheimer's disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds <b>1-10b</b> were synthesized through a two-step reaction. Results: Compounds <b>1-5b</b> showed more β-amyloid disaggregation ability than reference drugs rifampicin and donepezil ...[more]