The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.
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ABSTRACT:
SUBMITTER: Womersley JS
PROVIDER: S-EPMC6935155 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.
Womersley Jacqueline S JS Clauss Lara B LB Varathan Olivette O Engelbrecht Susan S Hemmings Sian M J SMJ Seedat Soraya S Spies Georgina G
BMC research notes 20191227 1
<h4>Objective</h4>Gene-environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 ...[more]
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