Ontology highlight
ABSTRACT:
SUBMITTER: Fan H
PROVIDER: S-EPMC6936115 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Fan Han H Demirci Utkan U Chen Pu P
Journal of hematology & oncology 20191229 1
Cancer heterogeneity is regarded as the main reason for the failure of conventional cancer therapy. The ability to reconstruct intra- and interpatient heterogeneity in cancer models is crucial for understanding cancer biology as well as for developing personalized anti-cancer therapy. Cancer organoids represent an emerging approach for creating patient-derived in vitro cancer models that closely recapitulate the pathophysiological features of natural tumorigenesis and metastasis. Meanwhile, canc ...[more]