Ontology highlight
ABSTRACT:
SUBMITTER: Kreitzburg KM
PROVIDER: S-EPMC6936734 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kreitzburg Kelly M KM van Waardenburg Robert C A M RCAM Yoon Karina J KJ
Cancer drug resistance (Alhambra, Calif.) 20180919
Despite progress in understanding molecular aberrations that contribute to the development and progression of ovarian cancer, virtually all patients succumb to drug resistant disease at relapse. Emerging data implicate bioactive sphingolipids and regulation of sphingolipid metabolism as components of response to chemotherapy or development of resistance. Increases in cytosolic ceramide induce apoptosis in response to therapy with multiple classes of chemotherapeutic agents. Aberrations in sphing ...[more]