Ontology highlight
ABSTRACT:
SUBMITTER: Kishikawa T
PROVIDER: S-EPMC6937407 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kishikawa Toshihiro T Maeda Yuichi Y Nii Takuro T Motooka Daisuke D Matsumoto Yuki Y Matsushita Masato M Matsuoka Hidetoshi H Yoshimura Maiko M Kawada Shoji S Teshigawara Satoru S Oguro Eri E Okita Yasutaka Y Kawamoto Keisuke K Higa Shinji S Hirano Toru T Narazaki Masashi M Ogata Atsushi A Saeki Yukihiko Y Nakamura Shota S Inohara Hidenori H Kumanogoh Atsushi A Takeda Kiyoshi K Okada Yukinori Y
Annals of the rheumatic diseases 20191107 1
<h4>Objective</h4>The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role in RA pathology by a comprehensive metagenome-wide association study (MWAS).<h4>Methods</h4>We conducted MWAS of the RA gut microbiome in the Japanese population (<i>n</i><sub>case</sub>=82, <i>n</i><sub>control</sub>=42) by using whole-genome shotgun sequencing of h ...[more]