Ontology highlight
ABSTRACT:
SUBMITTER: Bizarro J
PROVIDER: S-EPMC6938241 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Bizarro Jonathan J Bhardwaj Amit A Smith Susan S Meier U Thomas UT
Molecular biology of the cell 20191030 26
Cajal bodies (CBs) are nuclear organelles concentrating two kinds of RNA--protein complexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (sca)RNPs. Whereas the CB marker protein coilin is responsible for retaining snRNPs, the tether for scaRNPs is not known. Here we show that Nopp140, an intrinsically disordered CB phosphoprotein, is required to recruit and retain all scaRNPs in CBs. Knockdown (KD) of Nopp140 releases all scaRNPs leading to an unprecedented reduction in size of ...[more]