Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis.
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ABSTRACT:
SUBMITTER: Chou CW
PROVIDER: S-EPMC6938497 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis.
Chou Cheng-Wei CW Lin Ching-Heng CH Hsiao Tzu-Hung TH Lo Chia-Chien CC Hsieh Chih-Ying CY Huang Cheng-Chung CC Sher Yuh-Pyng YP
Scientific reports 20191231 1
The p53 gene is an important tumour suppressor gene. Mutant p53 genes account for about half of all lung cancer cases. There is increasing evidence for the anti-tumour effects of statins via inhibition of the mevalonate pathway. We retrospectively investigated the correlation between statin use and lung cancer prognosis using the Taiwanese National Health Insurance Research Database, mainly focusing on early-stage lung cancer. This study reports the protective effects of statin use in early-stag ...[more]
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