Mitochondrial Defects Drive Degenerative Retinal Diseases.
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ABSTRACT:
SUBMITTER: Ferrington DA
PROVIDER: S-EPMC6938541 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Mitochondrial Defects Drive Degenerative Retinal Diseases.
Ferrington Deborah A DA Fisher Cody R CR Kowluru Renu A RA
Trends in molecular medicine 20191123 1
Mitochondrial dysfunction is involved in the pathology of two major blinding retinal diseases, diabetic retinopathy (DR) and age-related macular degeneration (AMD). These diseases accumulate mitochondrial defects in distinct retinal subcellular structures, the vascular/neural network in DR and the retinal pigment epithelium (RPE) in AMD. These mitochondrial defects cause a metabolic crisis that drives disease. With no treatments to stop these diseases, coupled with an increasing population suffe ...[more]
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