An epigenome-wide association study of sex-specific chronological ageing.
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ABSTRACT:
SUBMITTER: McCartney DL
PROVIDER: S-EPMC6938636 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
An epigenome-wide association study of sex-specific chronological ageing.
McCartney Daniel L DL Zhang Futao F Hillary Robert F RF Zhang Qian Q Stevenson Anna J AJ Walker Rosie M RM Bermingham Mairead L ML Boutin Thibaud T Morris Stewart W SW Campbell Archie A Murray Alison D AD Whalley Heather C HC Porteous David J DJ Hayward Caroline C Evans Kathryn L KL Chandra Tamir T Deary Ian J IJ McIntosh Andrew M AM Yang Jian J Visscher Peter M PM McRae Allan F AF Marioni Riccardo E RE
Genome medicine 20191231 1
<h4>Background</h4>Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown to be associated with both age and sex. Here, we investigate age-by-sex differences in blood-based DNA methylation in an unrelated cohort of 2586 individuals between the ages of 18 and 87 years, with replication in a further 4450 individuals between t ...[more]
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