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Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus-uninfected Individuals in HPTN 077.

ABSTRACT: Studies in human immunodeficiency virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor-based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups.

SUBMITTER: Landovitz RJ 

PROVIDER: S-EPMC6938971 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus-uninfected Individuals in HPTN 077.

Landovitz Raphael J RJ   Zangeneh Sahar Z SZ   Chau Gordon G   Grinsztejn Beatriz B   Eron Joseph J JJ   Dawood Halima H   Magnus Manya M   Liu Albert Y AY   Panchia Ravindre R   Hosseinipour Mina C MC   Kofron Ryan R   Margolis David A DA   Rinehart Alex A   Adeyeye Adeola A   Burns David D   McCauley Marybeth M   Cohen Myron S MS   Currier Judith S JS  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20200101 2

Studies in human immunodeficiency virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor-based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups. ...[more]

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