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Antibacterial activity of lipo-?/sulfono-?-AA hybrid peptides.

ABSTRACT: Development of novel antimicrobial agents combating drug resistance is in an urgent need. Herein we report the design and synthesis of a series of short lipo-?/sulfono-?-AA hybrid peptides. Several short peptides exhibit potent and broad-spectrum antimicrobial activity toward both Gram-positive and Gram-negative bacteria. Membrane depolarization and fluorescence microscopy studies indicate that these short lipo-?/sulfono-?-AA hybrid peptides can mimic the mechanisms of HDPs to kill bacteria by disrupting bacterial membranes. In addition, these short peptides also show capability to eradicate the biofilm formation of E. coli even at very low concentration. The further development of lipidated ?/sulofono-?-AA hybrid peptides may lead to a new class of antibiotic agents to combat drug resistance.

SUBMITTER: Wei L

PROVIDER: S-EPMC6939128 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides.

Wei Lulu L Wang Minghui M Gao Ruixuan R Fatirkhorani Rojin R Cai Jianfeng J

European journal of medicinal chemistry 20191119

Development of novel antimicrobial agents combating drug resistance is in an urgent need. Herein we report the design and synthesis of a series of short lipo-α/sulfono-γ-AA hybrid peptides. Several short peptides exhibit potent and broad-spectrum antimicrobial activity toward both Gram-positive and Gram-negative bacteria. Membrane depolarization and fluorescence microscopy studies indicate that these short lipo-α/sulfono-γ-AA hybrid peptides can mimic the mechanisms of HDPs to kill bacteria by d ...[more]

PMID: 31771826

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