Ontology highlight
ABSTRACT:
SUBMITTER: Shin NY
PROVIDER: S-EPMC6939311 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Shin Nick Y NY Ryss Jonathan M JM Zhang Xin X Miller Scott J SJ Knowles Robert R RR
Science (New York, N.Y.) 20191001 6463
Deracemization is an attractive strategy for asymmetric synthesis, but intrinsic energetic challenges have limited its development. Here, we report a deracemization method in which amine derivatives undergo spontaneous optical enrichment upon exposure to visible light in the presence of three distinct molecular catalysts. Initiated by an excited-state iridium chromophore, this reaction proceeds through a sequence of favorable electron, proton, and hydrogen-atom transfer steps that serve to break ...[more]