Ontology highlight
ABSTRACT:
SUBMITTER: IJzerman AP
PROVIDER: S-EPMC6939755 | biostudies-literature | 1994 Jun
REPOSITORIES: biostudies-literature
IJzerman A P AP van der Wenden E M EM van Galen P J PJ Jacobson K A KA
European journal of pharmacology 19940601 1
The amino acid sequence of the rat adenosine A2A receptor and the atomic coordinates of bacteriorhodopsin were combined to generate a three-dimensional model for the adenosine A2A receptor. This model consists of seven amphipathic alpha-helices, forming a pore that is rather hydrophilic compared to the hydrophobic outside of the protein. Subsequently, a highly potent and selective ligand for this receptor, 2-(cyclohexylmethylidinehydrazino)adenosine (SHA 174), was docked into this cavity. A bind ...[more]