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Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.

ABSTRACT: Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our understanding of genetic architecture in all populations and ensure that genetic research is broadly applicable. To facilitate and promote research in multi-ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunities, challenges, solutions, and areas in need of development. Despite the perception that analyzing genetic data from diverse populations is difficult, it is scientifically and ethically imperative, and there is an expanding analytical toolbox to do it well.

SUBMITTER: Peterson RE 

PROVIDER: S-EPMC6939869 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.

Peterson Roseann E RE   Kuchenbaecker Karoline K   Walters Raymond K RK   Chen Chia-Yen CY   Popejoy Alice B AB   Periyasamy Sathish S   Lam Max M   Iyegbe Conrad C   Strawbridge Rona J RJ   Brick Leslie L   Carey Caitlin E CE   Martin Alicia R AR   Meyers Jacquelyn L JL   Su Jinni J   Chen Junfang J   Edwards Alexis C AC   Kalungi Allan A   Koen Nastassja N   Majara Lerato L   Schwarz Emanuel E   Smoller Jordan W JW   Stahl Eli A EA   Sullivan Patrick F PF   Vassos Evangelos E   Mowry Bryan B   Prieto Miguel L ML   Cuellar-Barboza Alfredo A   Bigdeli Tim B TB   Edenberg Howard J HJ   Huang Hailiang H   Duncan Laramie E LE  

Cell 20191010 3

Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our understanding of genetic architecture in all populations and ensure that genetic research is broadly applicable. To facilitate and promote research in multi-ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunities, chall  ...[more]

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