Ontology highlight
ABSTRACT:
SUBMITTER: Ajeti V
PROVIDER: S-EPMC6939997 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Ajeti Visar V Tabatabai A Pasha AP Fleszar Andrew J AJ Staddon Michael F MF Seara Daniel S DS Suarez Cristian C Yousafzai M Sulaiman MS Bi Dapeng D Kovar David R DR Banerjee Shiladitya S Murrell Michael P MP
Nature physics 20190408
How cells with diverse morphologies and cytoskeletal architectures modulate their mechanical behaviors to drive robust collective motion within tissues is poorly understood. During wound repair within epithelial monolayers <i>in vitro</i>, cells coordinate the assembly of branched and bundled actin networks to regulate the total mechanical work produced by collective cell motion. Using traction force microscopy, we show that the balance of actin network architectures optimizes the wound closure ...[more]