Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez HN
PROVIDER: S-EPMC6940392 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sanchez Helia N HN Moroney Justin B JB Gan Huoqun H Shen Tian T Im John L JL Li Tianbao T Taylor Julia R JR Zan Hong H Casali Paolo P
Nature communications 20200102 1
Short-chain fatty acids (SCFAs) butyrate and propionate are metabolites from dietary fiber's fermentation by gut microbiota that can affect differentiation or functions of T cells, macrophages and dendritic cells. We show here that at low doses these SCFAs directly impact B cell intrinsic functions to moderately enhance class-switch DNA recombination (CSR), while decreasing at higher doses over a broad physiological range, AID and Blimp1 expression, CSR, somatic hypermutation and plasma cell dif ...[more]