Unknown

Dataset Information

0

Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein level predicts recurrence of hepatitis B virus-related hepatocellular carcinoma after curative resection.


ABSTRACT: BACKGROUND/AIMS:To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. METHODS:Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (?2 years). RESULTS:A total of 170 patients with CHB were selected. During the follow-up period (median, 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+- M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ?2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ?2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001). CONCLUSION:WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.

SUBMITTER: Kim HS 

PROVIDER: S-EPMC6940487 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein level predicts recurrence of hepatitis B virus-related hepatocellular carcinoma after curative resection.

Kim Hye Soo HS   Kim Seung Up SU   Kim Beom Kyung BK   Park Jun Yong JY   Kim Do Young DY   Ahn Sang Hoon SH   Han Kwang-Hyub KH   Park Young Nyun YN   Han Dai Hoon DH   Kim Kyung Sik KS   Choi Jin Sub JS   Choi Gi Hong GH   Kim Hyon-Suk HS  

Clinical and molecular hepatology 20190627 1


<h4>Background/aims</h4>To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection.<h4>Methods</h4>Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years).<h4>Results</h4>A total of 170 p  ...[more]

Similar Datasets

| S-EPMC6687159 | biostudies-literature
| S-EPMC5378406 | biostudies-literature
| S-EPMC5564582 | biostudies-other
| S-EPMC8899980 | biostudies-literature
| S-EPMC9249794 | biostudies-literature
| S-EPMC7324360 | biostudies-literature
| S-EPMC5895864 | biostudies-other
| S-EPMC9409572 | biostudies-literature
| S-EPMC6116978 | biostudies-literature
| S-EPMC5419651 | biostudies-literature