Ontology highlight
ABSTRACT:
SUBMITTER: Podesta MA
PROVIDER: S-EPMC6940533 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Podestà Manuel A MA Binder Christian C Sellberg Felix F DeWolf Susan S Shonts Brittany B Ho Siu-Hong SH Obradovic Aleksandar A Waffarn Elizabeth E Danzl Nichole N Berglund David D Sykes Megan M
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20190813 1
Siplizumab, a humanized anti-CD2 monoclonal antibody, has been used in conditioning regimens for hematopoietic cell transplantation and tolerance induction with combined kidney-bone marrow transplantation. Siplizumab-based tolerance induction regimens deplete T cells globally while enriching regulatory T cells (Tregs) early posttransplantation. Siplizumab inhibits allogeneic mixed-lymphocyte reactions (MLRs) in vitro. We compared the impact of siplizumab on Tregs versus other T cell subsets in H ...[more]