Ontology highlight
ABSTRACT:
SUBMITTER: Kantas B
PROVIDER: S-EPMC6940912 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Kántás Boglárka B Börzsei Rita R Szőke Éva É Bánhegyi Péter P Horváth Ádám Á Hunyady Ágnes Á Borbély Éva É Hetényi Csaba C Pintér Erika E Helyes Zsuzsanna Z
International journal of molecular sciences 20191211 24
Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst<sub>4</sub> receptor without endocrine actions. Therefore, sst<sub>4</sub> is considered to be a novel target for drug development in pain including chronic neuropathy, which is an emerging unmet medical need. Here, we examined the in silico binding, the sst<sub>4</sub>-linked G-protein activation on stable receptor expressing cells (1 nM to 10 μM), and the ...[more]