Ontology highlight
ABSTRACT:
SUBMITTER: Lee AR
PROVIDER: S-EPMC6941136 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20191204 24
The proteasome inhibitor (PI), bortezomib (Btz), is effective in treating multiple myeloma and mantle cell lymphoma, but not solid tumors. In this study, we show for the first time that lercanidipine (Ler), an antihypertensive drug, enhances the cytotoxicity of various PIs, including Btz, carfilzomib, and ixazomib, in many solid tumor cell lines by inducing paraptosis, which is accompanied by severe vacuolation derived from the endoplasmic reticulum (ER) and mitochondria. We found that Ler poten ...[more]