Dataset Information

Cellulose Acetate/P4VP-b-PEO Membranes for the Adsorption of Electron-Deficient Pharmaceutical Compounds.

ABSTRACT: The prevalence of pharmaceutical compounds in surface and groundwater presents a rising threat to human health. As such, the search for novel materials that serve to avoid their release into the environment or for the remediation once in the water effluent is of utmost importance. The present work describes the fabrication of a cellulose acetate membrane modified with the block copolymer poly(4-vinylpyridine-b-ethylene oxide) (P4VP-b-PEO) crafted for the specific targeting and adsorption of electron-deficient pharmaceuticals (EDPs). The EDPs under study were sulfamethoxazole, sulfadiazine, and omeprazole. The results as part of this work present a thorough characterization of the prepared membranes by FTIR, contact angle measurement, and SEM images. Moreover, results show that the adsorptive character of the membrane correlates with the relative electron deficiency and spatial orientation of the contaminant. Interestingly, the addition of nominal 1% P4VP-b-PEO to the cellulose matrix helps to increase the adsorption efficiency of the membranes by at least 2-fold in most cases. For the compounds studied, the prepared membrane has a higher efficiency toward omeprazole followed by sulfamethoxazole and sulfadiazine. This work may serve to inspire the design and fabrication of selective soft materials for the adsorption and remediation of contaminants of emerging concern.

SUBMITTER: Penabad-Pena L

PROVIDER: S-EPMC6941198 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Cellulose Acetate/P4VP-b-PEO Membranes for the Adsorption of Electron-Deficient Pharmaceutical Compounds.

Penabad-Peña Laura L Herrera-Morales Jairo J Betancourt Miguel M Nicolau Eduardo E

ACS omega 20191218 27

The prevalence of pharmaceutical compounds in surface and groundwater presents a rising threat to human health. As such, the search for novel materials that serve to avoid their release into the environment or for the remediation once in the water effluent is of utmost importance. The present work describes the fabrication of a cellulose acetate membrane modified with the block copolymer poly(4-vinylpyridine-b-ethylene oxide) (P4VP-b-PEO) crafted for the specific targeting and adso ...[more]

PMID: 31909328

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Project description:In this work, we combined the non-solvent induced phase separation (NIPS) and further cross-linking by cations towards the preparation of nanofiltration membranes based on sodium alginate, a biodegradable, natural polymer. Acetone, ethanol, toluene, and hexane were used as non-solvents, and cations of calcium, silver, and aluminum-for polymer cross-linking, respectively. Results showed the precipitation strength of non-solvent played a noticeable role in the membrane's performance; for instance, the toluene permeability changed by four orders of magnitude with the decrease of precipitation strength of the non-solvent: acetone (Ptoluene = 0.1 kg∙m-2∙h-1∙bar-1) < ethanol (3 kg∙m-2∙h-1∙bar-1) < hexane (41 kg∙m-2∙h-1∙bar-1) < toluene (415 kg∙m-2∙h-1∙bar-1). It was shown that simultaneous precipitation and crosslinking in aqueous solutions AlCl3 or AgNO3 must be used in the preparation of alginate membranes for the highly selective recovery of pharmaceutical compounds from organic media. These membranes show rejection R = 90-93% of substances with MW = 626 g/mol and ethanol permeability PEtOH = 1.5-2.5 kg∙m-2∙h-1∙bar-1. For the highly selective recovery of pharmaceutical compounds from water, the method of obtaining membranes must be changed. Precipitation in toluene and then crosslinking in aqueous solutions of AlCl3 or AgNO3 must be used sequentially instead of simultaneous precipitation and crosslinking in aqueous solutions of the same inorganic salts. The permeability of such membranes varied from 0.44 to 7.8 kg∙m-2∙h-1∙bar-1 depending on the crosslinking cation in the alginate. The rejection of model substances with MW 350 and 626 g/mol were on the level of 99%. Alginate membranes can be used to solve separation problems in the pharmaceutical field, for example, to isolate antibiotics from their extractants and remove the same antibiotics from aqueous pharmaceutical waste to prevent their accumulation in the environment and the emergence of resistant genes and bacteria.

Dataset Information

Cellulose Acetate/P4VP-b-PEO Membranes for the Adsorption of Electron-Deficient Pharmaceutical Compounds.

Publications

Cellulose Acetate/P4VP-<i>b</i>-PEO Membranes for the Adsorption of Electron-Deficient Pharmaceutical Compounds.

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