Ontology highlight
ABSTRACT:
SUBMITTER: Li CW
PROVIDER: S-EPMC6941417 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Frontiers of medicine 20180730 4
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential i ...[more]