Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice.
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ABSTRACT:
SUBMITTER: Fry RC
PROVIDER: S-EPMC6941420 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Effects of Preconception and in Utero Inorganic Arsenic Exposure on the Metabolic Phenotype of Genetically Diverse Collaborative Cross Mice.
Fry Rebecca C RC Addo Kezia A KA Bell Timothy A TA Douillet Christelle C Martin Elizabeth E Stýblo Miroslav M Pardo-Manuel de Villena Fernando F
Chemical research in toxicology 20190708 8
In humans and mice, in utero exposure to inorganic arsenic (iAs) is associated with adverse health outcomes later in life. The contribution of preconception exposure to the adverse outcomes in offspring has never been studied. Here combined in utero and postnatal exposures produce insulin resistance in two collaborative cross strains. Furthermore, combined preconception and in utero exposure resulted in increased birth weight and developed insulin resistance in one strain. Thus, preconception ex ...[more]
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