Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an Actinomadura sp.
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ABSTRACT:
SUBMITTER: Yan JX
PROVIDER: S-EPMC6941472 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an <i>Actinomadura sp.</i>
Yan Jia-Xuan JX Chevrette Marc G MG Braun Doug R DR Harper Mary Kay MK Currie Cameron R CR Bugni Tim S TS
Organic letters 20190805 16
Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived <i>Actinomadura</i> sp. The presence of an unusual 4-imidazolidinone ring in madurastatins D1 and D2 inspired us to sequence the <i>Actinomadura</i> sp. genome and to identify the <i>mad</i> biosynthetic gene cluster, knowledge of which enables us to now propose a biosynthetic pathway. Madurastatin D1 and D2 are moderately active in antimicrobial ...[more]
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