Ontology highlight
ABSTRACT:
SUBMITTER: Koo PK
PROVIDER: S-EPMC6941814 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
PLoS computational biology 20191219 12
Although convolutional neural networks (CNNs) have been applied to a variety of computational genomics problems, there remains a large gap in our understanding of how they build representations of regulatory genomic sequences. Here we perform systematic experiments on synthetic sequences to reveal how CNN architecture, specifically convolutional filter size and max-pooling, influences the extent that sequence motif representations are learned by first layer filters. We find that CNNs designed to ...[more]