Extracellular vesicles for acute kidney injury in preclinical rodent models: a meta-analysis.

ABSTRACT: INTRODUCTION:Extracellular vesicles (EVs), especially stem cell-derived EVs, have emerged as a potential novel therapy for acute kidney injury (AKI). However, their effects remain incompletely understood. Therefore, we performed this meta-analysis to systematically review the efficacy of EVs on AKI in preclinical rodent models. METHODS:We searched PubMed, EMBASE, and the Web of Science up to March 2019 to identify studies that reported the treatment effects of EVs in a rodent AKI model. The primary outcome was serum creatinine (Scr) levels. The secondary outcomes were the blood urea nitrogen (BUN) levels, renal injury score, percentage of apoptotic cells, and interleukin (IL)-10 and tumour necrosis factor (TNF)-? levels. Two authors independently screened articles based on the inclusion and exclusion criteria. The meta-analysis was conducted using RevMan 5.3 and R software. RESULTS:Thirty-one studies (n =?552) satisfied the inclusion criteria. Pooled analyses demonstrated that the levels of Scr (SMD?=?-?3.71; 95% CI?=?-?4.32, -?3.10; P 

SUBMITTER: Liu C 

PROVIDER: S-EPMC6942291 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature