Ontology highlight
ABSTRACT:
SUBMITTER: Sugimori M
PROVIDER: S-EPMC6942439 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sugimori Makoto M Sugimori Kazuya K Tsuchiya Hiromi H Suzuki Yoshimasa Y Tsuyuki Sho S Kaneta Yoshihiro Y Hirotani Akane A Sanga Katsuyuki K Tozuka Yuichiro Y Komiyama Satoshi S Sato Takeshi T Tezuka Shun S Goda Yoshihiro Y Irie Kuniyasu K Miwa Haruo H Miura Yuuki Y Ishii Tomohiro T Kaneko Takashi T Nagahama Masatsugu M Shibata Wataru W Nozaki Akito A Maeda Shin S
Cancer science 20191224 1
According to cancer genome sequences, more than 90% of cases of pancreatic ductal adenocarcinoma (PDAC) harbor active KRAS mutations. Digital PCR (dPCR) enables accurate detection and quantification of rare mutations. We assessed the dynamics of circulating tumor DNA (ct-DNA) in patients with advanced PDAC undergoing chemotherapy using dPCR. KRAS G12/13 mutation was assayed by dPCR in 47 paired tissue- and ct-DNA samples. The 21 patients were subjected to quantitative ct-DNA monitoring at 4 to 8 ...[more]