Ontology highlight
ABSTRACT:
SUBMITTER: Chronister WD
PROVIDER: S-EPMC6942668 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chronister William D WD Burbulis Ian E IE Wierman Margaret B MB Wolpert Matthew J MJ Haakenson Mark F MF Smith Aiden C B ACB Kleinman Joel E JE Hyde Thomas M TM Weinberger Daniel R DR Bekiranov Stefan S McConnell Michael J MJ
Cell reports 20190101 4
A subset of human neocortical neurons harbors complex karyotypes wherein megabase-scale copy-number variants (CNVs) alter allelic diversity. Divergent levels of neurons with complex karyotypes (CNV neurons) are reported in different individuals, yet genome-wide and familial studies implicitly assume a single brain genome when assessing the genetic risk architecture of neurological disease. We assembled a brain CNV atlas using a robust computational approach applied to a new dataset (>800 neurons ...[more]