Dataset Information

Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species.

ABSTRACT: Malaria is a tropical parasitic disease caused by the Plasmodium genus, which resulted in an estimated 219 million cases of malaria and 435 000 malaria-related deaths in 2017. Despite the availability of the Plasmodium falciparum genome since 2002, 74% of the genes remain uncharacterized. To remedy this paucity of functional information, we used transcriptomic data to build gene co-expression networks for two Plasmodium species (P. falciparum and P. berghei), and included genomic data of four other Plasmodium species, P. yoelii, P. knowlesi, P. vivax and P. cynomolgi, as well as two non-Plasmodium species from the Apicomplexa, Toxoplasma gondii and Theileria parva. The genomic and transcriptomic data were incorporated into the resulting database, malaria.tools, which is preloaded with tools that allow the identification and cross-species comparison of co-expressed gene neighbourhoods, clusters and life stage-specific expression, thus providing sophisticated tools to predict gene function. Moreover, we exemplify how the tools can be used to easily identify genes relevant for pathogenicity and various life stages of the malaria parasite. The database is freely available at www.malaria.tools.

SUBMITTER: Tan QW

PROVIDER: S-EPMC6943069 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species.

Tan Qiao Wen QW Mutwil Marek M

Nucleic acids research 20200101 D1

Malaria is a tropical parasitic disease caused by the Plasmodium genus, which resulted in an estimated 219 million cases of malaria and 435 000 malaria-related deaths in 2017. Despite the availability of the Plasmodium falciparum genome since 2002, 74% of the genes remain uncharacterized. To remedy this paucity of functional information, we used transcriptomic data to build gene co-expression networks for two Plasmodium species (P. falciparum and P. berghei), and included genomic data of four ot ...[more]

PMID: 31372645

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Dataset Information

Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species.

Publications

Malaria.tools-comparative genomic and transcriptomic database for Plasmodium species.

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