SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway.

ABSTRACT: Although studies have revealed some of the pathological causes associated with prostate cancer progression, further studies are still needed. Shugoshin 1 (SGO1) is a protein essential for precise chromosome segregation during mitosis and meiosis. However, the role and mechanism of SGO1 in tumors and even prostate cancer is not completely clear. In this study, expression of SGO1 in human prostate tumors were higher than that of adjacent normal tissues and were positively correlated with the poor prognosis of prostate cancer patients. SGO1 expression levels are also higher in several prostate cancer cell lines. In cell experiments, knockdown of SGO1 reduced cell proliferation, migration, and invasion in vitro and in vivo, and also inhibited cell cycle progression of prostate cancer cells. In contrast, ectopic expression of SGO1 has the opposite effects. In addition, knockdown of SGO1 induces apoptosis in prostate cancer cells by promoting cleaved caspase-3, caspase-9, and PARP. Importantly SGO1 function is dependent on AKT. Inhibition of AKT activity by AKT inhibitor abolished the role of SGO1 overexpression in promoting cell proliferation and metastasis. Therefore, SGO1 promotes the proliferation and metastasis of prostate cancer through the AKT pathway, and can be considered as an effective candidate for developing an effective prostate cancer treatment strategy.

SUBMITTER: Chen Q 

PROVIDER: S-EPMC6943359 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature