Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
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ABSTRACT:
SUBMITTER: Niu M
PROVIDER: S-EPMC6943379 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice.
Niu Mengwei M Luo Zhihong Z Gong Shenhai S Win Sanda S Kaplowitz Neil N Jiang Yong Y Chen Peng P
The American journal of pathology 20191011 1
Acetaminophen (APAP) overdose-induced hepatotoxicity is the leading cause of drug-induced liver injury worldwide. The related injury pathogenesis is mainly focused on the liver. Here, the authors report that gut barrier disruption may also be involved in APAP hepatotoxicity. APAP administration led to gut leakiness and colonic epithelial chemokine (C-C motif) ligand 7 (CCL7) up-regulation. Intestinal epithelial cell (IEC)-specific CCL7 transgenic mice (CCL7<sup>tgIEC</sup> mice) showed markedly ...[more]
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