Ontology highlight
ABSTRACT:
SUBMITTER: El Hassouni B
PROVIDER: S-EPMC6943431 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
El Hassouni Btissame B Mantini Giulia G Immordino Benoît B Peters Godefridus J GJ Giovannetti Elisa E
Molecules (Basel, Switzerland) 20191204 24
<h4>Background</h4>Inhibition of ribosome biogenesis has recently emerged as a promising strategy for the treatment of metastatic tumors. The RNA polymerase I inhibitor CX-5461 has shown efficacy in a panel of cancer types and is currently being tested in clinical trials. However, further preclinical studies to unravel molecular mechanisms underlying the activity of this drug are warranted.<h4>Methods</h4>In this study, we have investigated the effects of CX-5461 on cell growth and migration of ...[more]