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Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action.

ABSTRACT: Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of Pueraria candollei var. mirifica, and 17?-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated transcription of the brain-derived neurotrophic factor (BDNF) and estrogen receptor (Er? and Er?) mRNAs. Like 17?-estradiol, puerarin also inhibited ovariectomy-induced suppression of neurogenesis in the dentate gyrus of the hippocampus (increased the number of doublecortin (DCX)-immunosuppressive cells). These results suggest that puerarin exerts antidepressant-like effects in OVX animals, possibly by attenuating the OVX-induced hyperactivation of the HPA axis and/or normalizing the downregulated transcription of BDNF and ER mRNA in the brain.

SUBMITTER: Tantipongpiradet A 

PROVIDER: S-EPMC6943479 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action.

Tantipongpiradet Ariyawan A   Monthakantirat Orawan O   Vipatpakpaiboon Onchuma O   Khampukdee Charinya C   Umehara Kaoru K   Noguchi Hiroshi H   Fujiwara Hironori H   Matsumoto Kinzo K   Sekeroglu Nazim N   Kijjoa Anake A   Chulikhit Yaowared Y  

Molecules (Basel, Switzerland) 20191213 24

Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of <i>Pueraria candollei</i> var. <i>mirifica</i>, and 17β-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated tran  ...[more]

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