First Synthesis of (-)-Altenuene-D3 Suitable as Internal Standard for Isotope Dilution Mass Spectrometry.
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ABSTRACT:
SUBMITTER: Sebald MA
PROVIDER: S-EPMC6943508 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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First Synthesis of <i>(-)</i>-Altenuene-D<sub>3</sub> Suitable as Internal Standard for Isotope Dilution Mass Spectrometry.
Sebald Michael A MA Gebauer Julian J Sommerfeld Thomas T Koch Matthias M
Molecules (Basel, Switzerland) 20191212 24
Metabolites from <i>Alternaria</i> fungi exhibit a variety of biological properties such as phytotoxic, cytotoxic, or antimicrobial activity. Optimization of a literature procedure culminated in an efficient total synthesis of <i>(-)</i>-altenuene as well as a stable isotope-labeled derivative suitable for implementation in a LC-MS/MS method for mycotoxin analysis. ...[more]
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