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Circulating Interleukin-6 Level, Dietary Antioxidant Capacity, and Risk of Colorectal Cancer.

ABSTRACT: Chronic inflammation is one of the causes of colorectal cancer (CRC), and circulating levels of inflammatory biomarkers have been linked to tumor promotion and progression. We aimed to evaluate the interleukin-6 (IL-6) level in CRC patients and determine whether a diet rich in antioxidants was associated with CRC. This study included 654 cases and 1312 controls matched for age and sex. We measured the plasma IL-6 concentration and estimated dietary antioxidant capacity based on oxygen radical absorbance capacity (ORAC) combined with a 106-item semiquantitative food frequency questionnaire. The IL-6 concentration was significantly increased in individuals with CRC (OR _{Q4 vs. Q1}, 95% CI = 6.23, 4.10-9.45, p < 0.001). High dietary ORAC showed an inverse association with CRC (total ORAC OR _{Q4 vs. Q1}, 95% CI = 0.26, 0.16-0.40, p < 0.001; total phenolics = 0.32, 0.21-0.50, p < 0.001). We found that low dietary ORAC was associated with a significant increase in CRC in the group with elevated IL-6 levels (total ORAC OR _{Q4 vs. Q1}, 95% CI = 4.34, 3.12-6.02, p < 0.001; total phenolics = 4.61, 3.33-6.39, p < 0.001). This study suggested an inverse association between dietary antioxidant capacity and IL-6 level among patients with CRC.

SUBMITTER: Kim J

PROVIDER: S-EPMC6943549 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Circulating Interleukin-6 Level, Dietary Antioxidant Capacity, and Risk of Colorectal Cancer.

Kim Jimi J Lee Jeonghee J Oh Jae Hwan JH Chang Hee Jin HJ Sohn Dae Kyung DK Shin Aesun A Kim Jeongseon J

Antioxidants (Basel, Switzerland) 20191128 12

Chronic inflammation is one of the causes of colorectal cancer (CRC), and circulating levels of inflammatory biomarkers have been linked to tumor promotion and progression. We aimed to evaluate the interleukin-6 (IL-6) level in CRC patients and determine whether a diet rich in antioxidants was associated with CRC. This study included 654 cases and 1312 controls matched for age and sex. We measured the plasma IL-6 concentration and estimated dietary antioxidant capacity based on oxygen radical ab ...[more]

PMID: 31795177

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Project description:The associations of various dietary or circulating antioxidants with the risk of all-cause mortality in the general population have not been established yet. A systematic search was performed in PubMed and Scopus, from their inception up to October 2017. Prospective observational studies reporting risk estimates of all-cause mortality in relation to dietary intake and/or circulating concentrations of antioxidants were included. Random-effects meta-analyses were conducted. Forty-one prospective observational studies (total n = 507,251) involving 73,965 cases of all-cause mortality were included. The RRs of all-cause mortality for the highest compared with the lowest category of circulating antioxidant concentrations were as follows: total carotenes, 0.60 (95% CI: 0.46, 0.74); vitamin C, 0.61 (95% CI: 0.53, 0.69); selenium, 0.62 (95% CI: 0.45, 0.79); β-carotene, 0.63 (95% CI: 0.57, 0.70); α-carotene, 0.68 (95% CI: 0.58, 0.78); total carotenoids, 0.68 (95% CI: 0.56, 0.80); lycopene, 0.75 (95% CI: 0.54, 0.97); and α-tocopherol, 0.84 (95% CI: 0.77, 0.91). The RRs for dietary intakes were: total carotenoids, 0.76 (95% CI: 0.66, 0.85); total antioxidant capacity, 0.77 (95% CI: 0.73, 0.81); selenium, 0.79 (95% CI: 0.73, 0.85); α-carotene, 0.79 (95% CI: 0.63, 0.94); β-carotene, 0.82 (95% CI: 0.77, 0.86); vitamin C, 0.88 (95% CI: 0.83, 0.94); and total carotenes, 0.89 (95% CI: 0.81, 0.97). A nonsignificant inverse association was found for dietary zinc, zeaxanthin, lutein, and vitamin E. The nonlinear dose-response meta-analyses demonstrated a linear inverse association in the analyses of dietary β-carotene and total antioxidant capacity, as well as in the analyses of circulating α-carotene, β-carotene, selenium, vitamin C, and total carotenoids. The association appeared to be U-shaped in the analyses of serum lycopene and dietary vitamin C. The present study indicates that adherence to a diet with high antioxidant properties may reduce the risk of all-cause mortality. Our results confirm current recommendations that promote higher intake of antioxidant-rich foods such as fruit and vegetables.

Dataset Information

Circulating Interleukin-6 Level, Dietary Antioxidant Capacity, and Risk of Colorectal Cancer.

Publications

Circulating Interleukin-6 Level, Dietary Antioxidant Capacity, and Risk of Colorectal Cancer.

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