Ontology highlight
ABSTRACT:
SUBMITTER: Yuan T
PROVIDER: S-EPMC6944132 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Yuan Tao T Chen Zibo Z Yan Fangjie F Qian Meijia M Luo Hong H Ye Song S Cao Ji J Ying Meidan M Dai Xiaoyang X Gai Renhua R Yang Bo B He Qiaojun Q Zhu Hong H
Molecular oncology 20191127 1
Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life-threatening cancers, and the high mortality rate is largely due to the metastasis. The sustained activation of Smad4 and transforming growth factor-β (TGF-β) is closely associated with advanced HCC metastasis. However, the regulatory mechanism underlying the aberrant activation of Smad4 and TGF-β pathway remains elusive. In this study, using a functional screen of USPs siRNA library, we identified ubiquitin-specific pro ...[more]