Ontology highlight
ABSTRACT:
SUBMITTER: Joshi BH
PROVIDER: S-EPMC6944210 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Joshi Bharat H BH Leland Pamela P Calvo Alfonso A Green Jeffrey E JE Puri Raj K RK
Cancer research 20081101 22
Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity IL-13 binding subunit and a tumor antigen, is amplified in a variety of human tumor cell lines and tumors in vivo. By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. Here, we show that IL-13Ralpha2 mRNA and protein are also up-regulated in PC-3 prostate tumor cells by recombinant AM (rAM) and human synthetic AM peptide in a d ...[more]